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Allergic Conjunctivitis  David Kinshuck
Birmingham patients can get anti-allergy treatment, see

This page explains a stepwise treatment for patients with allergic conjunctivitis. For more information about allergic conjunctivitis itself, particularly if you wear contact lenses, visit the web sites below.

 

 


Symptoms...how do your eyes feel

Allergic conjunctivitis is a common condition. Your eyes become red and very itchy, and generally your sight is good. You may notice a runny nose or feel unwell if you have a more severe allergy. The eyes then get better, and the condition then returns every now and again. 'Itchy red eyes' occuring now and again, particularly if you suffer from hey fever ro other allergies, is the main symptom.

If the allergy occurs during the hay fever season, then it is related to hay fever, and termed 'seasonal allergic conjunctivitis'. But if it occurs all the year round you are probably allergic to dust, and termed 'perennial'.
Alternatively you may be allergic to cat fur, for instance. Pollution in the air increases allergy rates considerably.

Some people are allergic to contact lens solutions. 

Many people with allergic eye disease also have dry eyes and blepharitis, which may also be helped with treatment. 'Dry eyes' feel as though they are burning; eyes with blepharitis feel irritable and gritty.

Anyone with sore eyes should ideally not use more tham 4 eye drops containing preservative a day in an eye. People with dry eyes need preservative free drops.

 

 


Medical treatment

 


Optichrom and related drops
Optichrom eye drops are virtually 100% safe for long term use and can be very helpful. They stop the 'allergy cells' on the surface of your eye, the mast cells, releasing chemicals that make your eyes irritable. This is the first drop to try, but if is it is not effective try the others below. As they work differently you may use them in addtion to Optichrom.

Nedocromil  (Rapitil) and Lodoxamide are more modern and quicker acting forms of Optichrom and should tried if Optichrom has not helped enough.


Livostin

Livostin is an antihistamine drop. Other similar drops include Optilast and Emadine and ketotifen. Ketotifen may be more effective, see and here. This may be used in addition to Optichrom. Also see.

 


Opatanol (olopatadine)

US name is Patanol. It is a mast cell stabiliser/antihistamine, and can be very effective. It is proving very popular, and some data indicates it is more effective than other drugs see and see . It is now the first choice for ophthalmologists who treat patients when the optichrom related drugs have not helped enough.

 


Antihistamine tablets

Antihistamine tablets such as Cetirizine can be very helpful, but there are many others. (Alternatives include Desloratidine (doses given), Levocetirizine (5mg >6y age), Loratidine (5mg >2-5y age, 10mg >6y age), Terfenidine (not with arrythmias).
Try them if your allergy is bad. They may make you too tired but are generally safe, and they help your runny nose and the fever part of hay fever.
With hay fever it is best to start the treatment early before the condition gets hold, as this way it is easier to control.
There are many types of anithistamine tablets and some make more people tired than others. Ask your doctor and pharmacist for advice.

 


Steroid drops
If using Nedocromil / Lodoxamide , Livostin, or olopatadine does not work, steroid drops may work. Again, they are usually used in addition to Nedocromil / Lodoxamide and Livostin or olopatadine.
However, at this stage you should pay detailed attention to avoiding the triggers to your allergy as below, especially if you have a dust allergy.

In practice very few people need steroid drops if they avoid dust (as below) or use the drops and antihistamine tablets above. Generally steroid drops are best avoided.

If you do have to use them, the main steroid drop is prednisolone minims, and this should not be used without an ophthalmologist's advice, unless your GP is experienced in its use and you only use it for short periods.
There are many ways to use the prednisolone drops. The 'minims' type have no preservative and are generally best for allergy patients.
If your eyes are red and itchy, you may need to use them quite often, perhaps 4 times a day. As soon as the redness fades, usually about 4 days, start to reduce the dose of the steroid to 3 and them 2 times a day.
Once the redness has faded, continue for a few days and then try to stop them.

If the redness and itch returns every time you stop, and as advised by your ophthalmologist, you may need to use a low dose regularly, such as once a day. This is reasonably safe during the hay fever season for short periods.

Steroid drops have many side effects if used in the wrong manner. You need to be certain that you do have 'allergic conjunctivitis' and not another condition, and most people can recognise when their eyes are red and itchy the condition has returned.
But if you have a scratchy and painful eye, you may have an ulcer and the drops should be stopped and you should get expert advice.
Similarly, if you need a lot of steroid drops for many months you may develop glaucoma, so you will need regular checks and expert advice. Long term use will lead to cataracts also. Even short term use of steroid drops can activate herpes simplex keratitis.

Very weak steroid drops, such as prednisolone 0.1 - 0.05% are available from Moorfields eye hospital and some others, and these may be safer and helpful.

 

Atopic keratoconjunctivitis
Here the lid is affected, and patients will have severe systemic disease. Treatment has been reviewed by JI McGill (with extracts here, no online links available) and here (tacrolimus). They will have asthma or eczema of the face. The condition fluctuates.

The lids need intensive treatment. Without meibomian gland secretions tears do not spread, and so a dry eye effect results, leading to corneal disease and ulcers.

  • check for allergens and if possible avoid allergens (discussed here for dust)
  • maintain on mast cell stablisiers (nedocromil or ledoxamide) 2 or 3 times a day
  • steroids only in acute exacerbations
  • treat lids with oxytetracyline 250mg once or twice a day, or doxcycline 100mg once daily
  • lubricate with preservative free tears (viscotears in milder cases)
  • severe cases may need systemic treatment, but topical tacrolimus has been suggested
  • beware of herpes simplex keratitis when on steroids (also glaucoma, cataracts, corneal melting), but nevertheless steroid drops are often needed.
 

 


Immunotherapy for hay fever (& seasonal allergic conjunctivitis)

In many parts of the country immunotherapy is available for hay fever sufferers, but not as far as I am aware in Birmingham. Some people dispute the effectiveness of immunotherapy, but it is probably very helpful for some people, and slightly less helpful for others.

Your GP will need to advise you about immunotherapy in your specific case, but if your hay fever is bad the medical literature advises it should be available to you and recommends you consult an immunologist.
Homeopathic remedies help some people, but not others, and are not suitable as a replacement for immunotherapeutic advice if your symptoms are severe and you need steroid tablets.

See  www.asthma.org.uk, especially if you have asthma.

Birmingham patients can get anti-allergy treatment, see

 


Dust allergy (& perennial allergic conjunctivitis): precautions

If you have a dust allergy there is plenty you can do. Visit the websites below for more details. This page has many details....although written for asthma patients, advice may be helpful.

  • Try a new pillow or ultra-clean towel over your pillow in bed. This might be particularly helpful if you have your conjunctivitis at night or when you wake up. Any regular pillow collects dust inside that after a while, and you can become allergic to it. If this helps buy a non-allergenic pillow with a special outer cover. After 5 years most pillows are 50% dust mite!
    Similarly, sleep on an ultra-clean towel, and if this helps buy special mattress and duvet covers. These can be expensive but can be very, very, helpful.
  • The dust mite is killed by freezing. Therefore, putting your pillow in the freezer for a few hours will kill all the mites. Try this, and if it helps it confirms you are allergic to dust. The dust mites accumulate, so you may need to repeat this every month. It may also help if you can put your mattress cover in the freezer, and your duvet and duvet cover, if they fit.
  • Washing bedding at high temperatures also kills the dust mite.
  • When hoovering..try to get someone else to do it...but if you cannot, try to dampen the floor first with a spray of water. When dusting, use a damp cloth.
  • Keep your rooms ventilated, and perhaps turn the heating down, especially when you are out. The dust mite (which is what people are allergic to) likes centrally heated non-ventilated rooms.
  • New carpets, or some people say wooden floors, help some people. Some people are allergic to their old sofa (any excuse for a new one, and a leather sofa is less allergenic). The current evidence concerning wooden floors is that they generally do not make all that much difference.
  • To diagnose your dust allergy, a trip abroad can be helpful. If you are allergic to the dust in your home a trip to the Bahamas can make you feel much better. If your allergy returns as soon as you come back, you have made the diagnosis, but the solution is more complex!
 

Lifestyle issues and Mediterranean diet

Lifestyle issues are critically important

 

 


Step-wise treatment summary
If allergic to dust or contact lens solutions, take appropriate actions as above
   
Nedocromil and Lodoxamide drops are completely safe. They stop the allergy cells, the 'mast cells', releasing the chemicals that make you itch. Optichrom (or Rapitil) may be effective in milder cases.
   

Livostin, Optilast and Emadine are antihistamine drops.
Ideally they should only be used for a short period. They make some people sleepy, but eye-wise are very safe. Try them in addition to the mast cell stabilising drops, perhaps later instead, to see which work best for you.
Olopatadine helps many people.

   

Antihistamine tablets such as Desloratidine (doses given) help. You may need a slightly higher than recommended dose if your hey fever is very bad. Piriton is stronger but makes most people sleepy.

   
If you are still having problems, look again at prevention, especially if you are allergic to dust. Anti-dust measures such as freezing bedding for a few hours or buying a new pillow or special covers can be extremely helpful.
At this stage it may be best to seek specialist help if you are still having severe problems, certainly seek your GPs help.

Treatment table, modified after Banerjee, Eye, 2005
commercial name constituent type
Otrivine-antistin antazoline & xyometazoline antihistamine and vasoconstrictor (weak)
Optilast azelastine antihistamine
Emadine emadastine antihistamine
Livostin levocabastine antihistamine

sodium chromoglycate
(many other names eg Optichrom)

sodium chromoglycate mast sell stabiliser (weak);
very safe
Rapitil nedocromil sodium mast sell stabiliser
Alomide lodoxamide mast sell stabiliser
Zaditen ketotifen mast sell stabiliser
Opatanol olopatidine mast sell stabiliser
Acular ketorolac prostoglandin inhibitor
Ocufen fluriprofen prostoglandin inhibitor
Voltarol diclofenac prostoglandin inhibitor
Vexol rimexolone steroid
generally needs specialist supervision
FML

fluromethalone

steroid
generally needs specialist supervision
prednisolone minims prednisolone steroid
generally needs specialist supervision
stronger steroid drops always needs specialist supervision, often on-going; often need systemic antihistamines
cyclosporine

Links

 



----------------------Eye pages website feedback -----this page edited December 2007----------------------