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   Biochemistry, Haematology & Immunology ranges plus Antibiotic Assay Guidance

 

 

Biochemistry Reference Ranges

Adult Reference Ranges


Note: These ranges are applicable from 10th April 2002 after the introduction of a new autoanalyser suite.
These ranges will may not be applicable to results reported before this time, but note that appropriate reference ranges will have been reported with results.

Reference ranges are subject to regular reviews.


For reference ranges of patients less than 18yrs, please contact the Consultant Clinical Scientist on Ext. 2254

This table is only an approximate guide, as the majority of reference ranges are age related, and quoted on the report form. Therefore, it is important that a patient's date of birth is recorded clearly on the request form.

Test

Units

Reference Range
Albumin g/L 35 - 50
ALT iu/L M:<41   F:<31
Alkaline phosphatase iu/L Age related ranges available. Contact Duty Biochemist.
Ammonia umol/L M:15-55   F:11.2-48.2
Amylase iu/L 28 - 100
AST iu/L M:<37   F:<31
Bicarbonate mmol/L 22.0 - 29.0

Bilirubin total

 umol/L <17
Bilirubin direct umol/L <5.1
Calcium mmol/L 2.10 – 2.55
Carbamazepine mg/L Therapeutic : 4.0 – 12.0
Creatine Kinase (CK) iu/L Males <200     Females <130

(Note ethnic specific ranges available. Contact Duty Biochemist)
Creatinine umol/L M:62-106   F:44-80
Chloride mmol/L 95 - 108
Cholesterol mmol/L <5.0 (target range)
CRP

mg/L

 <5
CSF Glucose mmol/L 2.2 – 3.9
CSF Protein g/L 0.15 – 0.45
Digoxin ng/ML Therapeutic : 0.9 – 2.0
Gamma GT iu/L M:10-71   F:6-42
Glucose mmol/L Fasting : 3.5 – 6.0
Iron umol/L M:10.6-28.3   F:6.6-26.0
Lactate mmol/L 0.5 – 2.2
LDH IU/L 240 – 480
Lithium mmol/L Therapeutic : 0.6 – 1.2
Magnesium mmol/L 0.7 – 1.0
Phenytoin mg/L Therapeutic : 10 – 20
Phosphate mmol/L 0.8 – 1.5
Potassium (Serum) mmol/L 3.5 – 5.3
Potassium (Plasma) mmol/L 3.3 - 4.5
Serum Osmolality mmol/kg 275 - 295
Sodium mmol/L 133 – 146
Theophylline mg/L Therapeutic : 10 – 20
TIBC umol/L 40.8 – 76.6
Total protein g/L 60 – 80
Triglyceride mmol/L <2.3
UIBC umol/L 19.7 – 66.2
Uric acid umol/L M:202-417   F:143-339
Urine protein g/L Random : <0.12 24 Hr: <1.5
Urea mmol/L 2.5 – 7.8


 

Analyte Ref range (adult) Units Comments
AFP 0.0 - 5.8 kU/L  
Androstenedione 2.1 - 10.8 nmol/L Male
1.0 - 11.5 nmol/L Female
BNP 0.0 -100 pg/mL Male
0.0 - 150 pg/mL Female
CA125 0.0 - 21 kU/L  
CA199 0 - 35 kU/L  
CEA <5.0 ug/L  
Cortisol 138 - 690 nmol/L 09:00 am
79 - 345 nmol/L Midnight
HCG 0.0 - 2.5 IU/L Male
0.0 - 5.0 IU/L Female
Ferritin 30 - 400 ug/mL Male
13 - 150 ug/mL Female
FSH 3.5 - 12.5 IU/L Follicular
4.7 - 21.5 IU/L Mid cycle
1.7 - 7.7 IU/L Luteal
25.8 - 134 IU/L Post-menopausal
0.7 - 11.1 IU/L Male
Folate 3.8 - 16.0 ng/mL  
LH 2.4 - 12.6 IU/L Follicular
14 - 95.6  IU/L Mid Cycle
1 - 11.4 IU/L Luteal
7.7 - 58.5 IU/L Postmenopausal
0.8 - 7.6 IU/L Male
Oestradiol 46 - 607 pmol/L Follicular
315 - 1828 pmol/L Mid cycle
161 - 774 pmol/L Luteal
<201 pmol/L Post-menopausal
0 - 206 pmol/L Male
Progesterone 1.0 - 6.3 nmol/L Follicular
2.5 - 7.4 nmol/L Mid cycle
2.3 - 69 nmol/L Luteal
<3.2 nmol/L Post-menopausal
Prolactin 102 - 496 mIU/L Female
86 - 324 mIU/L Male
PSA 0.0 - 2.7 ng/mL 0 - 49 years
0.0 - 3.4 ng/mL 50 - 59 years
0.0 - 4.4 ng/mL 60 - 69 years
0.0 - 5.5 ng/mL 69 - 79 years
0.0 - 6.5 ng/mL 79 years +
PTH 15 - 65 pg/mL  
SHBG 15 - 48 nmol/L Male
26 - 110 nmol/L Female
Testosterone 9.9 - 27.8 nmol/L Male
<1.6 nmol/L Female

 

Immunology Tests Reference Intervals

Adult Reference Ranges
Test Reference Range
Complement C3 0.75 - 1.65 g/L
Complement C4 0.14 - 0.54 g/L
Total Immunoglobulin E (IgE) <200 kU/L
Caeruloplasmin 0.24 - 0.71 g/L
Immunoglobulin G (IgG) Age 15-45 yrs 6.0 - 16.0 g/L
Age 45 yrs 6.0 - 16.0 g/L
Immunoglobulin A (IgA) Age 15-45 yrs 0.8 - 2.8 g/L
Age 45 yrs 0.8 - 4.0 g/L
Immunoglobulin M (IgM) Age 15-45 yrs 0.5 - 1.9 g/L
Age 45 yrs 0.5 - 2.0 g/L
Tissue transglutaminase antibodies (TTG) Adult 0 - 15 U/mL  Negative
>15 U/mL   Positive
Rheumatoid Factor (RF) Adult <20 IU/mL  Negative
20 - 60 IU/mL  Weak positive
>60 IU/mlL Positive
Cardiolipin Antibodies IgG Cardiolipin Antibodies 0-15 U/mL  Negative
>15 U/mL  Positive
IgM Cardiolipin Antibodies 0-15 U/mL  Negative
>15 U/mL  Positive
Thyroid Antibodies (Thyroid Peroxisomal - TPO) Adult 0-34 IU/mL  Negative

 

Paediatric levels may vary considerably from the above adult ranges. Paediatric ranges are contained in “Handbook of Clinical Immunochemistry” (Eighth Edition) or advice may be obtained from the laboratory.

To Discuss reference ranges for patients below the age of 18 please contact Clinical Immunology at Heartlands Hospital (ext 42105)

          

Haematology Reference Ranges

Test

Age

Range

Units

Haemoglobin

Up to 14 days

12.0 – 25.0

g/dl
 

14 days to 1 year

11.0 – 13.5

g/dl
 

1 to 10 years

11.0 – 14.5

g/dl
 

Males over 10 years

12.0 – 18.0

g/dl
 

Females over 10 years

11.0 – 16.0

g/dl

Red Cell Count

Up to 14 days

4.0 – 6.0

1012/L
 

14 days to 12 weeks

3.2 – 4.8

1012/L
 

12 to 52 weeks

3.6 – 5.2

1012/L
 

1 to 6 years

4.1 – 5.5

1012/L
 

7 to 12 years

4.0 – 5.4

1012/L
 

Males over 12 years

4.5 – 5.5

1012/L
 

Females over 12 years

3.8 – 4.8

1012/L

Reticulocytes

All

0.2 – 2.0

%

Haematocrit

Adult Male

0.40 – 0.50

  
 

Adult Female

0.36 – 0.46

  

Mean Cell Volume (MCV)

Up to 14 days

90 – 120

fL

 

14 days to 10 years

76 – 96

fL
 

Over 10 years

80 – 99

fL

M.C.H.

All

27.0 – 32.0

pg

M.C.H.C.

All

31.0 – 35.9

%

R.D.W.

All

10.0 – 14.5

  

Platelets

All

150 – 450

109/L

White Cell Count

Up to 14 days

6.0 – 26.0

109/L
 

Over 10 years

3.5 – 11.0

109/L
 

In Pregnancy

3.5 – 15.0

109/L

Neutrophils

Up to 14 days

1.5 – 13.0

109/L
 

14 days to 1 year

1.9 – 7.0

109/L
 

1 to 10 years

1.9 – 8.0

109/L
 

Over 10 years

1.9 – 9.0

109/L

Lymphocytes

Up to 14 days

2.0 – 11.0

109/L
 

14 days to 1 year

3.0 – 10.5

109/L
 

1 to 10 years

1.4 – 6.5

109/L
 

Over 10 years

0.9 – 4.5

109/L

Monocytes

Up to 14 days

0.1 – 3.1

109/L
 

Over 10 years

0.1 – 2.0

109/L

Eosinophils

All

0 – 0.5

109/L

Basophils

All

0 – 0.2

109/L
Paediatric ESR

Male & Female 0 – 1 4 years

0 - 20

mm/hour
Vacutainer ESR

Male & Female 0 - 7 years

0 - 20

mm/hour

 

Male 7 - 14 years

0 - 15

mm/hour
 

Female 7 - 14 years

0 - 20

mm/hour

 

Male 14 – 50 years

0 - 7

mm/hour
 

Female 14 – 50 years

0 – 9

mm/hour
 

Male 51 to 60 years

0 – 9

mm/hour
 

Female 51 to 60 years

0 – 14

mm/hour
 

Males over 60 years

0 – 10

mm/hour
 

Females over 60 years

0 – 15

mm/hour

Plasma Viscosity

All

1.5 – 1.72

mPas

INR / APPT ratio

All

0.8 – 1.2

  

Fibrinogen

All

1.7 – 4.0

g/L

 


Microbiology Reference Ranges

Antibiotic Assays : Gentamicin and Vancomycin
Performed Monday to Saturday at Good Hope Hospital, but prior notification required by the laboratory. Samples should reach the laboratory by 4.30 pm on Monday to Friday and 12 noon on Saturday.
Samples should be taken by a doctor looking after the patient and not a Phlebotomist.
The samples required are as follows:-

 
VANCOMYCIN  normal renal function.   See B.N.F. for dose
Sample Required Timing Reference Range
Pre dose only 5 ml clotted blood taken 
5 - 30 mins before dose		 5 - 20 mg/L

Please state dose, time of dose and time blood was taken on request form.

GENTAMICIN once daily dosing.  Discuss dose with Consultant Microbiologist
Sample Required Timing Reference Range
6 - 13 hour post dose only 5 ml clotted blood taken 
6 - 13 hours after dose.  Please state exact time		 See nomogram and/or discuss with Microbiologist

Please state dose, time of dose and time blood was taken on request form.

 

GENTAMICIN standard dosing.   See B.N.F. for dose
Sample Required Timing Reference Range
Pre and post dose levels. Pre dose 5 mins before dose.  Post dose 1 hour after dose. Pre dose < 2mg/L
  Post dose 3-5 mg/L for Streptococcus Endocarditis
 

 

 Post dose 5-10 mg/L for other infection

Please state dose, time of dose and time blood was taken on request form.