Some
epidemiology
|
-
see
-
100,000 blind
people in the UK,
-
64,000 blind from
ARMD
-
There are about 26,000 new cases of wet AMD in the UK each year
and the condition affects more women than men. The condition usually
affects people who are over 50 years old and the risk increases significantly
with age. The most commonly cited risk factor for AMD is cigarette
smoking; the risk of developing AMD is 3.6 times greater for current
and former smokers than for people who have never smoked. (NICE)
-
770,000 have early
ARMD
-
84:16 female:male
ratio
-
Major impact:
-
falls...x8 risk
of fractured hip, x4 risk of needing home care
-
each line of vision
represents about 20% 'quality of life'
-
person's own
self-esteem is reduced
-
risks
of soft drusen progressing
-
more about drusen
and progression Wang
et al
-
Participants
with light iris colour had twofold the risk of AMD progression
of those with dark or intermediate iris colours
-
lipofuscin
(in drusen etc) originates from vitamin A
-
there is at lease a 10x difference between countries...eg Japan and
China have very low rates.
-
33%
of people >75y develop armd also
-
Early treatment
is more effective (here)..this
suggests screening would be helpful. I recommend all high risk patients
with soft drusen, especially smokers, to see their optometrist every
6 months for an assessment...waiting for symptoms is probably too late
(limited evidence for this at present)
-
Genes controlling
breakdown of other chemicals (including pollutants) may also contribute
to ARMD, see
-
at presentation of exudative ARMD: 24%
were wholly/predominately classic, 38% minimally classic, 38% occult
no classic. Only the 24% were suitable for PDT. (Poster, RCO, 2005)
-
autofluoresence findings are related to
macular function. I expect this will become a useful examination
procedure, but you need a scanning laser ophthalmoscope see
-
there are skin autofluoresence changes Mulder
2010
-
28,000 Cases of ARMD
causing visual loss in people aged 75 years and above in the United
Kingdom may be attributable to smoking.see
-
We know urban pollution increases the risk of
heart disease so that it equals the risk of smoking 20 cigarettes a
day, here.
This it is likely that urban pollution will also cause many cases
of ARMD. Definitive evidence is awaited. For cities the size of Birmingham
and London similar numbers of patients affected by smoking will be
affected by pollution. (nearly 500 and 5500 cases respectively.)
-
Occult ARMD is merely an earlier stage of CNV,
see
-
ARMD is much less common in Japan and China,
and much more common in countries such as Greenland.
-
one if the biggest problems is the inability
to find patients with early
CNV.
-
results are better without
risk factors
-
peripapillary CNV are related to armd:
the
associations of peri-papillary
CNV are
52(45.2%), age-related maculopathy (ARM);
45 (39.1%), idiopathic;
5 (4.3%), multifocal choroiditis;
3 (2.6%), angioid streaks;
2 (1.7%), histoplasmosis;
2 (1.7%), choroidal osteoma;
1 (0.9%), optic disc drusen;
1 (0.9%), congenital disc anomaly
(3 [2.6%]) peripapillary pseudopodal pigment epithelial a
(1 [0.9%]) choroidal atrophy
Second-eye involvement was observed in 19.8% of patients over a median
follow-up of 2 years
-
CNV
are associated with staphylomas
-
CNV are related to many inflamatory conditions, including sarcoid See
CNV due to sarcoid membrane other
healthy eye
-
Drusen
can be graded.
-
US epidemiology (Archives
2011)
stage |
description |
0a |
nil |
0b |
small hard drusen <63µ |
1a |
soft distinct drusen > 63µ |
1b |
pigmentary abnormalities only |
2a |
soft indistinct drusen >125 µ
or reticular drusne only |
2b |
soft indistinct drusen >63 <125µ
with pigmentary abnormalities |
3 |
soft indistinct drusen/reticular >125µ
with pigmentary abnormalities |
4 |
atrophic/neovascular ARMD |
|