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Good Hope Hospital Eye Clinic
 

Myopic Macular Degeneration

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Low vision & Macula Disease

Myopia and macula

The macula is the central part of the retina. It is responsible for detailed vision: for reading, seeing faces, watching TV etc. 

Myopia is discussed here. Essentially myopia is an optical condition caused by having an  extra-long eyeball, so the eye may be 28 mm long instead of the normal 22.3mm, for example.

Because the eyeball is extra long the retina becomes very thin and may become damaged. If the macula is damaged (the central area of the retina), central vision will be affected. There may be distortion with bendy lines, or there may be a patch in the centre with no vision.

macula..where light is focused

In myopia the eye is extra long, and the retina extra thin. See
This may lead to damage to the central area of the retina (the macula).

 


Myopic macular degeneration ...atrophy

The main type of macula change in myopia is thinning of the retina in the macula area. This is not treatable, and gets worse slowly with age.

Central vision is affected, and reading, TV, crossing roads, seeing bus numbers, become difficult.

Low visual aids and help from the low vision team can be very helpful indeed. Everyone keeps their side vision, and no one becomes completely blind. Generally the worst outcome is partial sight.  

More severe thinning (atrophy) may occur after CNV (immediately below).

Myopic retinal changes may progress 2010

thin atrophic patches
develop in the macula area

macular scar diagram ARMD

photo    enlarge

 


Myopic CNV

In this type of myopic macula disease, new vessels grow in the macula area. 5% of highly myopic eyes (more than -6.00d) develop CNV.

This is similar to wet ARMD, but in myopia it may occur in much younger people. However, it is much commoner in older people with myopia.

These new vessels are called 'CNV'...choroidal new vessels or choroidal neoovascularisation, as the blood vessels originate in the choroid and grow under the retina.

The CNV cause retinal leakage and swelling. The condition progresses to cause a scar in the macular area. If the scar is small, sight is reasonable; if large, the sight can be very poor.

The long term prognosis is not good: most eyes develop less than <6/60 vision. Younger patients have a better prognosis..the CNV get walled off.

All types of wet ARMD (CNV) will progress 4 times faster in smokers, a 400% increase. In addition to smoking, high blood pressure, poor diet, lack of exercise increase the likelihood of progression and progression rate.

Treatment/details page

early cnv (macular degeneration)

New vessels growing under the central retina in myopia  (similar anatomically to regular CNV)     enlarge      photo    photo    

Myopic CNV Arevalo , Ruiz-Moreno,     Avastin, Chan 2008     Wakabayashi 09

Some CNV are related to newly developed areas of lacquer cracks Eye 2011.

 


Treatment of myopic CNV

  • Standard treatment is now anti-VEGF drugs Avastin/Lucentis.
  • Avastin injections can be very helpful. Some small lesions, for instance, may respond to 1-2 injections Eye 2011.
  • Lucentis can be very effective with few injections BJO 2011. 5 injections over 2 years. Retina 11.
  • Young patients Retina 2011
  • PDT
    • can be very effective, but most treatment now is anti-VEGF drugs Avastin/Lucentis.
       (VIP study: 5 PDT sessions; Liverpool observations: 3 sessions) see   Retina 2011 (lower dose).
    • Suggest start with anti-VEGF (with 3 injections especially in older patients, may be fewer in younger), see 4 weeks later, and if still active proceed with PDT
    • With PDT only need a 500� border (a 1000� border is needed in other types of CNV: Liverpool observatons). A smaller border causes less retinal atrophy.
    • triple therapy may be helpful, that is single session photodynamic therapy (PDT), intravitreal bevacizumab (Avastin) and  intravitreal triamcinolone .
The address of this site ('org' changing to 'nhs') is changing from http://www.goodhope.org.uk/departments/eyedept/ to http://www.goodhope.nhs.uk/departments/eyedept/
Eye website feedback -- Heartlands -- page edited October 2011 -- Public transport to Good Hope --