Studies published and in progress David Kinshuck 2007 |
Level 1 b..the best quality research
In progress |
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PDT...VIP & TAP studies |
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PDT is not as effective as Lucentis, and often does not preserve enough vision, and much less than Lucentis. It is available in many centres, and is available on the NHS. It is laser treatment, with 3 month intervals..about 4 treatments are needed. PDT was not very helpful at all for Occult CNV., Many people wonder if it would be helpful in addition to Lucentis/Avastin. and it the combination is being investigated. in the Mount Blanc |
Macugen ...VISION study |
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See Review. Macugen was not as effective as Lucentis and is nearly the same price. Monthly injections are needed at the beginning, as Lucentis and Avastin. |
Lucentis and classic CNV: Anchor study |
This is is the main Lucentis and classic CNV study. Some patients noticed improvement in vision, and certainly results were a lot better than PDT alone. |
Lucentis and occult CNV: Marina study |
This is is the main Lucentis and occult CNV study. Lucentis and Avastin seem to be the only treatments that really help occult CNV, but Lucentis is the drug with the research proving this is the case. |
PIER ....Lucentis every 3 months (after 3 injections) |
See Pier treatment consists of
Many people noticed an improvement of vision initially but this was lost due to recurrences occurring between the 3 month gaps between injections see. |
PRONTO ...Lucentis according to symptoms (after 3 injections) |
See Pronto treatment consists of
Many patients noticed an improvement of vision initially and this was maintained. Repeat injections were given if vision reduceds, macular thickness increased, or and haemorrhage was visible In practice this may be modified (one colleague suggests)
This is the likely model for treatment around the world for the time being, unless combination treatment is given. |
extra injections are needed if the conditions recurs/reactivates, but not otherwise |
Mount Blanc study...Lucentis combined with PDT |
See This study consists of
Many people believe that the combination treatment will reduce the number of Lucentis injections needed ....we await results. |
EXCITE study...Lucentis combined with PDT |
See Another study like the Mount Blanc above |
Avastin |
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Brachytherapy |
Problems, issues |
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Abbreviations |
CNV | choroidal new vessels (i.e. neovascular
macular degeneration, or 'wet'). Blood vesssels growing through the retina
under the macula. Also called CCNV. |
CNVM or CNVm | a choroidal neovascular membrane, that is a network of CNV, although in practice this means the same thing as CNV |
ARM | age-related macular disease |
ARMD | age-related macular degeneration |
PDT | photodynamic therapy (for classic sub-foveal neovascular ARMD ) |
Occult CNV | hard-to-see neovascular ARMD (based
on angiogram) blood vessels growing under the retina and leaking (but the leakage is late) |
Classic CNV | easy-to-see neovascular ARMD (based on angiogram) blood vessels growing under the retina and leaking |
dry ARMD | thinning (and other changes) of the central retina |
PED | pigment epithelial detachment, a type of wet ARMD |
Rip | a pigment epithelial rip or tear |
VEGF | Vascular endothelial growth factor...the main chemical that makes blood vessels grow in ARMD |
RAP | retinal angiomatous proliferation |
OCT / scans | optitcal coherence tomogram: a 3 dimensional photograph of the macula, called a scan |
VMC | Virtaul macular clinic..patients attend for an OCT and the scan is interpreted later, and the patient contact if another anti-vegf injection is needed |
wet (armd) | wet age-related macular degeneration, with CNV as above (blood vessels growing and leaking under the retina, usually under the macula) |
neovasularisation | similar meaing to wet armd |
macula | the centre of the retina that sees detailed vision like faces and reading |
anti-VEGF / injection | drugs that reduce growth and leaking from the new blood vessels under the retina in arnd, or on the retina in diabetes etc. They are gvine by injection into the eye |
GP | general pratitioner |
drusen | a type of aging change of the retina...tiny white spots/areas |
The address of this site ('org' changing to 'nhs') is changing from http://www.goodhope.org.uk/departments/eyedept/ to http://www.goodhope.nhs.uk/departments/eyedept/ |
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